A capital efficient, flexible model for companies pursuing healthcare innovations

Companies

These innovative companies are working to rapidly deliver better solutions to the world’s healthcare challenges.

 

ACTUS Biotechnologies: Convoy Therapeutics and EnduRx Pharmaceuticals (subsidiaries of ACTUS Biotechnologies)

Origin: Tucson AZ and San Diego, CA | Leadership: John Muraski, President

Focus: Therapeutics and Aesthetics

ACTUS Biotechnologies

Convoy’s technology platform focuses on solving major unmet needs in aesthetics and pharmaceutical markets by creating novel topical
products that are more effective, safer and easier to use; EnduRx is developing therapeutics that specifically target diseased tissue, with the front-line program being focused on the development of a targeted nanosystem for the treatment of Glioblastoma Multiforme (GBM).

 

Alector LCC

Origin: San Francisco, CA | Leadership: Arnon Rosenthal, CEO and Co-founder; Tillman Gerngross, Co-founder; Asa Abeliovich, Co-founder; Errik Anderson, Co-founder

Focus: Therapeutics

Alector is dedicated to the discovery and development of novel therapeutics for Alzheimer’s disease, other forms of dementia, and mechanistically related neurodegenerative disorders.

 

 

Alector LLC

Amarantus BioScience Holdings, Inc.

Origin: San Francisco, CA | Leadership: Gerald E. Commissiong, President, CEO and Co-Founder

Focus: Therapeutics and Diagnostics

Amarantus BioScience Holdings, Inc.

Amarantus BioScience Holdings, Inc. (“Amarantus”) is a biotechnology company discovering and developing treatments and diagnostics for diseases associated with neurodegeneration and apoptosis (programmed cell death).

 

Amplyx Pharmaceuticals

Origin: San Diego, CA | Leadership: Dinu Sen, CEO

Focus: Therapeutics

Amplyx Pharmaceuticals

Improves the therapeutic index of small molecule drugs by creating new chemical entities or therapeutic combinations with existing drugs.

 

Arcturus Therapeutics, Inc

Origin: San Diego, CA | Leadership: Joseph E. Payne, Founder and CEO; Pad Chivukula, Founder and CSO

Focus: Therapeutics

Arcturus Therapeutics, Inc

Arcturus is poised to become an industry leader in RNAi technologies for the treatment of rare orphan diseases.

 

Assembly Pharmaceuticals

Origin: Bloomington, Indiana and San Francisco, CA │ Leadership: Founders: Uri Lopatin, CMO; Adam Zlotnick, CSO; William Turner, Head of Chemistry; Derek Small, Executive Chair; Richard Dimarchi, Director

Focus: Small Molecule Antivirals

Curative therapy for Hepatitis B

Assembly Pharmaceuticals

 

Bell Biosystems, Inc.

Origin: Menlo Park, CA │ Leadership: Dr. Caleb B. Bell III, Founder and Chief Executive Officer; Daniel Bell, Founder and Chief Financial Officer

Focus: Synthetic Biology

Bell Biosystems, Inc.

Bell Biosystems develops synthetic organelles to add new functions to cells; our first product, the Magnelle, creates a magnetic phenotype in labeled cells which enables in vivo tracking using MRI.

 

Clinical Metabolomics (ClinMet)

Origin: Redwood City, CA | Leadership: Yesh Subramanian, CEO

Focus: Diagnostics & Pharma Services

Arcturus Therapeutics, Inc

Clinical trial based metabolomics platform for pharma to improve drug efficacy, reduce drug toxicity and identify mechanistic pathways for personalized medicine.

 

Cognuse

Origin: San Diego, CA and Tallinn, Estonia | Leadership: Andres Mellik, CEO & Co-Founder; Olari Koresaar, COO & Co-Founder; Daniil Harik, CTO & Co-Founder

Focus: Therapeutics and Diagnostics

Cognuse

Cognuse Inc. is a leading cognitive rehabilitation platform provider helping hospitals and rehabilitation clinics better assess and treat patients with neurological conditions such as strokes, TBI, ADHD, Alzheimer’s, MCI and Multiple Sclerosis. Cognuse platform hosts a number of virtual exercises that are strongly related to real life themes by focusing on restoring and improving executive functions of the brain.

 

CURx Pharmaceuticals

Origin: San Diego, Ca | Leadership: Dinu Sen, CEO and Founder

Focus: Therapeutics

CURx Pharmaceuticals

Clinical development of therapeutic strategies that address currently unmet medical needs.

 

DNAtrix

Origin: Houston, Texas | Leadership: Frank Tufaro, CEO

Focus: Biotechnology

DNAtrix

With a focus on brain tumors, we are in clinical development with highly potent oncolytic viruses to trigger anti tumor immunity.

 

Everist Genomics

Origin: Ann Arbor, MI | Leadership: Thomas Everist, Chairman

Focus: Personalized Medicine and Diagnostics

Everist Genomics

Develops and commercializes medically unique molecular and sensor based diagnostics, prognostics and therapeutic selection technologies for cancer and cardiovascular diseases, which help physicians improve medical outcomes and reduce the total cost of care.

 

Glycosensors and Diagnostics

Origin: Athens, GA | Leadership: Robert Woods, Founder & President; Lori Yang, Founder & CSO

Focus: Biotechnology

Glycosensors and Diagnostics

Provides enabling technologies for applications in glycoscience

 

Hera Therapeutics Inc.

Origin: Del Mar, CA | Leadership: Karl Y Hostetler, CEO

Focus: Therapeutics

Hera Therapeutics Inc.

Using a novel new medicinal chemistry platform, HTI is focused on the development and commercialization of direct acting antivirals for infections with the human papilloma virus, human and animal retroviruses and herpes group viruses.

 

Misfolding Diagnostics

Origin: San Diego, CA | Leadership: Undisclosed

Focus: Diagnostics

Misfolding Diagnostics

Research and development of mechanism-based, proprietary biomarker and in vitro immunodiagnosis products for the early detection of protein amyloid diseases.

 

NeuroGeneration

Origin: Los Angeles, CA | Leadership: Michel F. Levesque, Founder and Chairman

Focus: Biotechnology

NeuroGeneration

NeuroGeneration is a clinical stage biotechnology company with neural stem cell products targeting neurological disorders caused by cell loss or injury. It also identifies new targets for endogenous repair in the treatment of neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, Multiple Sclerosis, etc.

 

Neurolixis

Origin: San Diego, CA | Leadership: Adrian Newman-Tancredi, CSO

Focus: Therapeutics

Neurolixis

Design and develop novel small molecule compounds against a number of targets in the CNS targeting treatment-resistant depression, cognitive deficits in schizophrenia, symptomatic treatment of Parkinson's disease and developmental disorders such as Rett syndrome.

 

NeuroTransit, Inc.

Origin: San Diego, CA | Leadership: Brian Spencer, Co-Founder & Chief Scientist; Mike Dunn, Co-Founder & CEO

Focus: Biopharamaceutical

NeuroTransit, Inc.

NeuroTransit uses proprietary technology for the development of drug products that cross the blood-brain barrier (BBB) to treat neurologic, metabolic and oncologic diseases of the brain.

 

Nirmidas Biotech, Inc.

Origin: Stanford, CA | Leadership: Meijie Tang, CEO/Co-founder; Hongjie Dai, scientific founder

Focus: Biotechnology and Diagnostics

 

R&D and commercialization of high sensitivity detection platforms of biological systems for applications in the life science research, clinical research, and in vitro diagnostics.

 

Perlstein Lab

Origin: San Francisco, CA | Leadership: Ethan O. Perlstein, Founder

Focus: Therapeutics

Perlstein Lab generates precision drug candidates for orphan disease patients.

 

Perlstein Lab

PHusis Therapeutics Inc.

Origin: Houston, TX | Leadership: Lynn Kirkpatrick, CEO

Focus: Novel small molecule therapeutics against critical oncology targets

PHusis is using novel approaches to more rapidly develop small molecule inhibitors of pleckstrin homology (PH) domain signaling proteins critical in a number of diseases including oncology, where current projects include inhibitors of AKT/PDPK1 signaling and oncogenic KRAS and NRAS.

 

PHusis Therapeutics Inc.

Portable Genomics, Inc.

Origin: Bordeaux, France | Leadership: Patrick Merel, Founder and CEO

Focus: Wireless Genomics

Develops a mobile platform with a consumer-based approach to facilitate the understanding and use of genomic data linked with medical and lifestyle information, targeting pharma, healthcare and consumer markets.

 

 

Portable Genomics, Inc.

 

Primordial Genetics

Origin: San Diego, CA | Leadership: Helge Zieler, Founder and CEO

Focus: Renewable Fuels & Chemicals

Primordial Genetics is focused on developing genetic solutions for improvement of complex traits relating to product yield in microbes and higher organisms.

 

Primordial Genetics

Renascions

Origin: San Diego, CA | Leadership: Henry Pan, CEO

Focus: Biopharmaceutical/Clinical Diagnostics/Bioinformatics

Renascions

Focused on improving trial outcomes by selecting the right patient cohort, thereby potentially improving drug efficacy in oncology, metabolic disorders, cardiovascular diseases, viral infections and immunological diseases.

 

Sialix, Inc.

Origin: San Diego, CA | Leadership: Jeff Behrens, CEO

Focus: Therapeutics/Nutrition

Sialix, Inc.

Sialix is developing products based on new biological discoveries of non-human sialic acids, their dietary role and inflammatory consequences, and their potential impact on cancer, cardiovascular, and other inflammatory-mediated diseases.

 

Sienna Labs

Origin: San Diego, CA | Leadership: Todd Harris, Founder & CEO

Focus: Medical Device

Sienna Labs

Developing a first-in-class approach to treat acne and rejuvenate health and beauty of the skin based on the science of plasmonic resonance.

 

Siferon Therapeutics

Origin: San Diego, CA | Leadership: Elisabeth Gardiner, CSO

Focus: Therapeutics

Siferon Therapeutics

Discovery and development of small molecule drugs that block inflammatory signaling in the brain. Our goal is provide life changing disease modifying therapeutics for cognitive impairment and brain injury.

 

Silicon Biosystems

Origin: Bologna, Italy | Leadership: Giusepp Giorgini, CEO

Focus: Instrumentation

Silicon Biosystems

Proprietary lab-on-a-chip technology platform designed to individually identify, manipulate and sort specific cells within a heterogeneous population.

 

SillaJen

Origin: Busan, South Korea | Leadership: Co-CEOs: Yong-Han Lee and Eun-Sang Moon, Founder: Tae-Ho Hwang

Focus: Therapeutics

Silicon Biosystems

A world-leading R&D company in immunotherapeutic oncolytic virus and viral gene therapies for critical unmet medical needs.

 

SiteOne Therapeutics

Origin: Redwood City, CA | Leadership: Co-Founders; George Miljanich - CEO, President, Chair of Board; John Mulcahy, Director of R&D, Board Secretary; David Yeomans, Board Member, consultant; Justin Du Bois - Board Member, consultant; Sandip Biswal - Board Member, consultant

Focus: Therapeutics and Diagnostics

SiteOne, founded by Stanford University researchers, is developing safer, more effective, non-narcotic pain medicines and novel imaging diagnostics for locating pain generators by targeting sodium channels in pain-sensing nerves.

 

SiteOne Therapeutics

Symic Biomedical

Origin: Purdue University, IN and San Francisco, CA | Leadership: Founders: John Paderi, Kate Stuart, and Alyssa Panitch

Focus: Therapeutics

Symic Biomedical

Symic Biomedical is developing a novel class of compounds that target the extracellular matrix, and have numerous acute and chronic clinical applications.

 

telmedx

Origin: San Diego, CA | Leadership: Richard L. Anglin, President & CEO

Focus: Telemedicine

telmedx

Live medical-grade video™ and high-resolution image capture from a patient’s mobile phone for clinician triage, remote diagnosis, follow-up care, drug compliance, and health status monitoring, all without the patient having to visit a brick-and-mortar medical facility.

 

TEM Systems

Origin: Munich, Germany | Leadership: Robert Hillman

Focus: Diagnostics

 

Medical diagnostic systems that provide a comprehensive profile of a patient's coagulation status.

 

Tiatros, Inc.

Origin: San Francisco, CA | Leadership: Kimberlie Cerrone, Co-founder and CEO; Joydip Homchowdhury, Co-founder and Chief Product Officer

Focus: Digitial Health

Tiatros dramatically improves efficiency across the healthcare sector by connecting all of the people, clinical information, and real-time health data that is needed to support truly collaborative patient care, clinical research, and clinical trials inside a private, secure mobile cloud.

 

Tiatros, Inc.

Vaxenta Biotechnologies

Origin: San Diego, CA | Leadership: Boris Markosian, Founder and CEO; Brandon Dolan, Director of scientific research; Daniel Dempsey, Director of operations; Thomas Ichim, CSO

Focus: Therapeutics

Vaxenta Biotechnologies

Vaxenta focuses on the development and commercialization of safe, natural, and effective cancer therapies.

 

VLP Biotech, Inc

Origin: San Diego, CA | Leadership: Dave Milich, Founder & CEO; Yemi Onakunle, President

Focus: Vaccines

VLP Biotech, Inc

Developing safe, efficacious and cost effective vaccines based on our patented highly immunogenic virus-like-particle platform.

 

Wellspring Biosciences

Origin: San Diego, CA | Leadership: Troy Wilson, President & CEO

Focus: Therapeutics

Wellspring Biosciences

Discovery and development of small molecule drugs that target signal transduction networks for the treatment of cancer and other diseases.

 

Whole Biome, Inc.

Origin: San Francisco, CA │ Leadership: Colleen Cutcliffe, Co-Founder, CEO; John Eid, Co-Founder, CSO; James Bullard, Co-Founder CTO

Focus: Diagnostics/Therapeutics

Whole Biome, Inc.

Whole Biome is ushering in a revolution in diagnostics and therapeutics where each individual's treatment will be driven by a comprehensive understanding and a targeted equilibration of their microbiome.

 

Wibi+Works, LLC

Origin: New Orleans, LA | Leadership: Aline M. Betancourt, Founder & CSO; Ruth S. Waterman, CEO

Focus: Therapeutics

Wibi+Works, LLC

Develops uniform and predictable cell-based therapies for diseases associated with inflammation.

 

Yolia Health

Origin: Mexico City, Mexico | Leadership: Alberto Osio, Founder & CEO

Focus: Medical Device

Yolia Health

Non-invasive treatment to correct presbyopia using personalized contact lenses and specially formulated eye drops.

 

*Some companies have opted for non-disclosure and are therefore not included in this list.